Reaktionsgleichung
C(O[C:4]([CH2:6][C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:8])=[O:5])C.C[O-].[K+].Cl[CH2:18][C:19]#[N:20]>CO>[C:19]([C:18]1[S:8][C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[CH:6][C:4]=1[OH:5])#[N:20]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 30 °C
Versuchsvorschrift
205 g of O-n-butyl 2-ethoxycarbonylthioacetate were added at 30° C. to a solution of 70 g of potassium methylate in a liter of methanol and the mixture was stirred for 10 minutes at 30° C. 75.5 g of chloroacetonitrile were added all at once to the mixture which was stirred for an hour at 40° C. and then a solution of 70 g of potassium methylate in 300 ml of methanol. The mixture was stirred for 6 hours at room temperature and was evaporated to dryness. The residue was washed with ethyl acetate and ether and was dried. The residue was then dissolved in water and the aqueous solution was acidified with concentrated hydrochloric acid and was vacuum filtered. The recovered precipitate was washed with water, dried and chromatographed over silica gel. Elution with 6-4 cyclohexane-ethyl acetate yielded 81 g of 2-cyano-3-hydroxy-5-n-butoxy-thiophene melting at 107° C.
Aufarbeitung
- stirringwas stirred for an hour at 40° C.
- stirringThe mixture was stirred for 6 hours at room temperature
- customwas evaporated to dryness
- washThe residue was washed with ethyl acetate and ether
- customwas dried
- dissolutionThe residue was then dissolved in water
- filtrationfiltered
- washThe recovered precipitate was washed with water
- customdried
- customchromatographed over silica gel
- washElution with 6-4 cyclohexane-ethyl acetate
Quellen und Nachweise
- ORD-Eintrag
- ord-c1e45e078eb043519707870911ab0059
- Quelldatensatz
- uspto-grants-1978_12
- Patentnummer
- US04128562
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