2-(Methylsulfonamido)phenylacetonitrile → N-[2-(2-aminoethyl)phenyl]methanesulfonamide

HRID 656271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656271
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]#[N:14])(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][CH2:13][NH2:14])(=[O:4])=[O:3]

Komponenten

4

Edukt 1

HCID 691184052-(Methylsulfonamido)phenylacetonitrile

Produkt 1

HCID 20848391N-[2-(2-aminoethyl)phenyl]methanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

(2-Methanesulfonylaminophenyl)acetonitrile (300 mg) was mixed with 10% palladium/carbon (catalytic amount) in methanol (20 ml) and the mixture was stirred under hydrogen gas atmospheres for 48 hours. After confirming the completion of the reaction using TLC, the resulting mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The following procedure was carried out using the concentrate which was not purified.

Aufarbeitung

  1. filtrationthe resulting mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. concentrationconcentrate which
  4. customwas not purified

Quellen und Nachweise

ORD-Eintrag
ord-234744b45fc34bb790657b2e28e616eb
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071650B2

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