Phenethyl Isothiocyanate → 1-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthiourea

HRID 656289

Reaktionsgleichung

Reaktionsgleichung von HRID 656289
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH2:8].[N:9]([CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[C:10]=[S:11]>C(OCC)(=O)C>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][NH:8][C:10]([NH:9][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[S:11]

Komponenten

4

Edukt 2

HCID 16741Phenethyl IsothiocyanateHCID 2776207(1-methyl-1H-pyrrol-2-yl)methanamine

Produkt 1

HCID 590880071-(1-methyl-1H-pyrrol-2-ylmethyl)-3-phenethylthioureaAusbeute 60,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

(1-methyl-1H-pyrrol-2-yl)methylamine (65 mg) and (2-isothiocyanatoethyl)benzene (100 mg) were dissolved in ethyl acetate (20 ml) and the solution was stirred for 12 hours. After the completion of the reaction, the resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3) to yield the compound 17-3 (97 mg, 60%) as a brown liquid.

Aufarbeitung

  1. customAfter the completion of the reaction
  2. customthe resulting mixture was purified by column-chromatography (ethyl acetate/hexane=1/3)

Quellen und Nachweise

ORD-Eintrag
ord-60190a4c30bd418ea67d301a066e7155
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071650B2

Verknüpfte Notizen

Wird geladen…