Phosphoric Acid → 3-(Benzyloxy)-1,2-propanediol

HRID 656315

Reaktionsgleichung

Reaktionsgleichung von HRID 656315
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:14][O:13]C(C)(C)[O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(=O)(O)(O)O.[OH-].[Na+].C([O-])([O-])=O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3]>O.C(O)C>[CH2:1]([O:8][CH2:9][CH:10]([OH:11])[CH2:14][OH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 1004Phosphoric AcidHCID 14798Sodium HydroxideHCID 857952,2-Dimethyl-4-((phenylmethoxy)methyl)-1,3-dioxolaneHCID 2483886611097-59-9

Produkt 1

HCID 980723-(Benzyloxy)-1,2-propanediol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Into a 1 L beaker were weighed 222 g (1.0 mol) of 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane prepared in 1-2, 250 ml of ethanol, and 400 ml of distilled water, and the whole was adjusted to pH 2 with phosphoric acid. With introducing nitrogen thereinto, the solution was heated to 70° C. After 1.5 hours of the reaction, the solution was adjusted to pH 7.0 with sodium hydroxide. The resulting salt was subjected to adsorption treatment with an adsorbent “KYOWAAD 1000” (manufactured by Kyowa Hakko Kogyo Co., Ltd.) and then subjected to solvent removal to obtain 3-benzyloxy-1,2-propanediol.

Aufarbeitung

  1. customAfter 1.5 hours of the reaction
  2. customsubjected to solvent removal

Quellen und Nachweise

ORD-Eintrag
ord-df30cbdd00a54e0bb1676e48eb262a3f
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071712B2

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