Nitric Acid → (+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

HRID 656388Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656388
[N+:1]([O-:4])(O)=[O:2].[CH3:5][N:6]1[C:10]2([CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]>O>[CH3:5][N:6]1[C:10]2([CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[C:14]([N+:1]([O-:4])=[O:2])[CH:13]=3)[CH2:18]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 18440308(+/-)-3-Methyl-spiro[imidazolidine-4,2'-indane]-2,5-dione

Produkt 1

HCID 18440305(+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To stirred fuming (90%) nitric acid (100 mL) was slowly added (±)-3-methyl-spiro[imidazolidine-4,2′-indane]-2,5-dione (4.5 g, 20.9 mmol) in portions over 30 min. The reaction mixture was diluted with H2O (200 mL) and the precipitate was collected by filtration, washed with H2O and dried in vacuo to give the title compound. MS: m/z=262 (M+1).

Aufarbeitung

  1. customover 30 min
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with H2O
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9831e63671604dc19186e7cbb99f12d9
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071771B2

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