Hydrochloric Acid → HCID 68575364, Verbindung

HRID 656463Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656463
C([N:8]1[CH:13]([C:14]#[N:15])[CH2:12][CH2:11][CH2:10][C:9]1([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[C:16]#[N:17])C1C=CC=CC=1.[ClH:26].[H][H]>CO.[Pd]>[ClH:26].[NH2:17][CH2:16][C:9]1([CH2:18][C:19]([OH:21])=[O:20])[CH2:10][CH2:11][CH2:12][CH:13]([CH2:14][NH2:15])[NH:8]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 86629994HCID 86629994, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 68575364HCID 68575364, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 6.00 mmol of tert-butyl (1-benzyl-2,6-dicyanopiperidin-2-yl)acetate in 40 ml of methanol is admixed with 2 ml of 37% strength aqueous hydrochloric acid and 0.600 g of 10% Pd/C. The reaction mixture is hydrogenated with 4 bar of hydrogen at 22° C. for 18 hours. The reaction mixture is filtered over Hyflo and the filtrate is evaporated. From the residue the crude title compound is identified on the basis of the Rf value. The title compound is used without further purification in the next stage.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered over Hyflo
  2. customthe filtrate is evaporated
  3. customThe title compound is used without further purification in the next stage

Quellen und Nachweise

ORD-Eintrag
ord-e836a627a44e4f1a816e2b1e751d1ee8
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071773B2

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