Sodium Hydroxide → Furo[2,3-c]pyridin-5-ylmethanol

HRID 656967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 656967
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.[OH-].[Na+]>O1CCOCC1.O>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 22047292HCID 22047292, Verbindung

Produkt 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanolAusbeute 70,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%).

Aufarbeitung

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customThe organic fractions were separated
  3. customdried
  4. customthen evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-dd3c8144f9af4fc7a42c9df27d594f6a
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08071592B2

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