Gamma-Butyrolactone → 4-(7,8-Dimethoxy 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-oxobutan-1-ol

HRID 657564

Reaktionsgleichung

Reaktionsgleichung von HRID 657564
[CH3:1][O:2][C:3]1[C:13]([O:14][CH3:15])=[CH:12][C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.C([Li])CCC.[C:21]1(=[O:26])[O:25][CH2:24][CH2:23][CH2:22]1.[Cl-].[NH4+]>C1COCC1.CCCCCC>[CH3:1][O:2][C:3]1[C:13]([O:14][CH3:15])=[CH:12][C:6]2[CH2:7][CH2:8][N:9]([C:24](=[O:25])[CH2:23][CH2:22][CH2:21][OH:26])[CH2:10][CH2:11][C:5]=2[CH:4]=1

Komponenten

7

Edukt 4

HCID 7302Gamma-ButyrolactoneHCID 25517Ammonium ChlorideHCID 129234297,8-Dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 178418339Butyllithium

Produkt 1

HCID 685296684-(7,8-Dimethoxy 1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-oxobutan-1-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8058HexaneLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

To 6.0 g (29 mmol) of 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine in 30 mL of THF, at 0° C., there are added, dropwise, over 15 minutes, 11.6 mL (29 mmol/1 eq.) of 2.6M n-butyl lithium solution in hexane. The mixture is then cooled to about −78° C. and poured dropwise, over 10 minutes, into a solution of 2.7 mL (34.8 mmol/1.2 eq.) of gamma-butyrolactone in 15 mL of THF. Stirring is carried out at −78° C. for 30 minutes and the temperature is then brought to −30° C. and held there for 1 hour; the temperature is then allowed to return to ambient temperature, where stirring is carried out for 48 hours. The mixture is poured into 75 mL of saturated aqueous ammonium chloride solution and is then extracted twice with 120 mL of ethyl acetate. The combined organic phases are washed with 150 mL of saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated. The residue is taken up in 300 mL of ethyl acetate and washed twice with 75 mL 1M aqueous hydrochloric acid solution. The combined aqueous acid phases are re-extracted twice with 100 mL of dichloromethane. The organic phases are combined, dried over magnesium sulphate and concentrated to yield the desired product.

Aufarbeitung

  1. waitis carried out at −78° C. for 30 minutes
  2. customis then brought to −30° C.
  3. waitheld there for 1 hour
  4. customto return to ambient temperature
  5. stirringwhere stirring
  6. waitis carried out for 48 hours
  7. extractionis then extracted twice with 120 mL of ethyl acetate
  8. washThe combined organic phases are washed with 150 mL of saturated aqueous sodium chloride solution
  9. dry with materialdried over magnesium sulphate
  10. concentrationconcentrated
  11. washwashed twice with 75 mL 1M aqueous hydrochloric acid solution
  12. extractionThe combined aqueous acid phases are re-extracted twice with 100 mL of dichloromethane
  13. dry with materialdried over magnesium sulphate
  14. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-fbe0b291f5364ffb92efc451837123d6
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076325B2

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