5-(Azidomethyl)-2-methylpyrimidine → (2-Methylpyrimidin-5-yl)methanamine

HRID 657749Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 657749
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[N+]=[N-]>C(OCC)(=O)C.[Pd]>[CH3:11][C:8]1[N:9]=[CH:10][C:5]([CH2:4][NH2:1])=[CH:6][N:7]=1

Komponenten

4

Edukt 1

HCID 545950225-(Azidomethyl)-2-methylpyrimidine

Produkt 1

HCID 21294601(2-Methylpyrimidin-5-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 5-(azidomethyl)-2-methylpyrimidine (2.0, 13.4 mmol) in ethyl acetate (100 mL), and 10% Pd—C (4.0 g) was stirred under H2 (1 atm) for 1.5 hr. The catalyst was filtered off and filtrate was concentrated in vacuo to afford a white solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated in vacuo
  3. customto afford a white solid

Quellen und Nachweise

ORD-Eintrag
ord-b72392e4d85f48d1980ff7238dcb0187
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076345B2

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