(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine → (R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 657782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 657782
C([N:8]1[CH2:30][CH2:29][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:16][C@@H:17]([C:19]3[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:24]=3)[CH3:18])[C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:28][C:25]([F:26])([F:27])[C:22]1[N:21]=[CH:20][C:19]([C@H:17]([NH:16][C:15]2[C:10]3[CH2:9][NH:8][CH2:30][CH2:29][C:11]=3[N:12]=[CH:13][N:14]=2)[CH3:18])=[CH:24][CH:23]=1

Komponenten

4

Edukt 1

HCID 59840708(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

Produkt 1

HCID 59840692(R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amineAusbeute 98,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of (R)-6-benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (3.55 g, 8.59 mmol), 10% palladium on charcoal (740 mg), and methanol (60 mL) were stirred under hydrogen (1 atm) for 15 h. The catalyst was filtered off through Celite and the filter cake was washed with MeOH (3×30 mL). The filtrate was concentrated to obtain an off-white foam (2.74 g, 98% yield).

Aufarbeitung

  1. filtrationThe catalyst was filtered off through Celite
  2. washthe filter cake was washed with MeOH (3×30 mL)
  3. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-76b044b0dd6b41dbbafce2f1e6f88750
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08076345B2

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