1,1-Dimethylhydrazine → alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

HRID 65796

Reaktionsgleichung

Reaktionsgleichung von HRID 65796
[N:1]([CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([O:7]CC)=[O:6])=[C:2]=[O:3].[CH3:15][N:16]([CH3:18])[NH2:17].C(Cl)Cl>C(O)(=O)C>[CH3:15][N:16]([CH3:18])[NH:17][C:2]([NH:1][CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([OH:7])=[O:6])=[O:3]

Komponenten

5

Edukt 3

HCID 59761,1-DimethylhydrazineHCID 6344DichloromethaneHCID 54068691alpha-Isocyanato-2-thiopheneacetic acid, ethyl ester

Produkt 1

HCID 54530029alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 4.2 g. (0.02 mole) of DL-α-isocyanato-2-thiopheneacetic acid, ethyl ester and 1.2 g. (0.02 mole) of N,N-dimethylhydrazine in 80 ml. of methylene chloride is stirred overnight. The solution is concentrated and to the syrupy residue are added 10 ml. of 2N sodium hydroxide solution. After stirring for 30 minutes, a clear yellow solution results. By the addition of acetic acid, 3.9 g. of α-dimethylhydrazinocarbonylamino-2-thiopheneacetic acid are obtained, m.p. 208°-210°.

Aufarbeitung

  1. concentrationThe solution is concentrated and to the syrupy residue
  2. additionare added 10 ml
  3. customa clear yellow solution results

Quellen und Nachweise

ORD-Eintrag
ord-208d1fa98d07437e8ee5455d106b3405
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04128724

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