(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate → 4-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

HRID 6587

Reaktionsgleichung

Reaktionsgleichung von HRID 6587
C([O:8][C:9]1[CH:28]=[CH:27][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:26])([F:25])[F:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:24])([F:25])[F:26])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:27][CH:28]=1

Komponenten

3

Edukt 1

HCID 22850730(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate

Produkt 1

HCID 145492174-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl esterAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2.2 g of [R]-1-trifluoromethylheptyl 4-benzyloxybenzoate, (13) 100 mg of PdOH/C in 50 ml of ethyl acetate was stirred at RT over night under H2 atmosphere. Then the catalyst was filtered out and filtrate was evaporated to dryness to give the pure compound in yield of 99%.

Aufarbeitung

  1. filtrationThen the catalyst was filtered out
  2. customfiltrate was evaporated to dryness
  3. customto give the pure compound in yield of 99%

Quellen und Nachweise

ORD-Eintrag
ord-3687b0a5c976428fb52ff00b4203cdb7
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07083832B2

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