Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate → 2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65922Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 65922
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]>CO.O=[Pt]=O>[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[NH:11][CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]

Komponenten

4

Edukt 1

HCID 4407258Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate

Produkt 1

HCID 227563502-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The product of Example II (2.5 g, 0.01 m) was dissolved in MeOH (250 ml). The catalyst, PtO2 (0.5 g), was added and the mixture was hydrogenated at 42 p.s.i. for 3 hrs. Filtration and removal of the solvent in vacuo yielded a white solid. Crystallization from MeOH afforded the product as a white solid; m.p. 140°-141° C.

Aufarbeitung

  1. filtrationFiltration and removal of the solvent in vacuo
  2. customyielded a white solid
  3. customCrystallization from MeOH

Quellen und Nachweise

ORD-Eintrag
ord-d50ec719b5ab40d785f03502f8272481
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04129653

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