Hexachloroethane → 4-(2-Chlorooxazol-5-yl)benzonitrile

Temperatur

-78 °C

To a solution of 4-Oxazol-5-yl-benzonitrile (3 g, 17.65 mmol) in anhydrous THF (80 mL) at −78° C. under an argon atmosphere was slowly added a solution of LiHMDS (21.2 mL, 1 M in THF, 21.2 mmol). After 1 h at −78° C., solid hexachloroethane (6.275 g, 26.48 mmol) was added. The mixture was then stirred at −78° C. for 1 h and allowed to slowly warm to room temperature and stir for 3 h. The reaction was diluted with AcOEt/H2O (50 mL/15 mL). The organic layer was washed with brine, dried with MgSO4 and filtered. After removal of solvent the solid obtained was recrystallize from Hexane to give the title compound as a white solid (2.95 g, 82%). m.p.=144° C.

1. temperatureto slowly warm to room temperature
2. stirringstir for 3 h
3. washThe organic layer was washed with brine
4. dry with materialdried with MgSO4
5. filtrationfiltered
6. customAfter removal of solvent the solid
7. customobtained
8. customwas recrystallize from Hexane

ORD-Eintrag

ord-e78b697eaa13435da6d81b1c6f83a030

Quelldatensatz

uspto-grants-2011_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08080669B2