Diethyl Ether → 7-Chloro-1-methyllepidinium iodide

HRID 6602

Reaktionsgleichung

Reaktionsgleichung von HRID 6602
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C[I:14].[CH2:15](OCC)C>CC#N>[I-:14].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N+:9]2[CH3:15])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 1704377-Chloro-4-methylquinoline

Produkt 1

HCID 220163717-Chloro-1-methyllepidinium iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A portion of the 7-chlorolepidine (80 mg) prepared as above was methylated by heating with CH3I (0.5 ml) in CH3CN (1 ml) at reflux for two hours. The mixture was treated with diethyl ether, followed by centrifugation, to give a yellow powder.

Aufarbeitung

  1. temperatureat reflux for two hours
  2. customto give a yellow powder

Quellen und Nachweise

ORD-Eintrag
ord-6a873647e2b44ce99055068705e47796
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07083982B2

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