Potassium Carbonate → HCID 57742155, Verbindung

HRID 660287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660287
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][C:7]=1[OH:19])=[O:4].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[O:4]=[C:3]1[CH2:2][O:19][C:7]2[CH:8]=[C:9]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:10]=[CH:11][C:6]=2[NH:5]1

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 57742180HCID 57742180, Verbindung

Produkt 1

HCID 57742155HCID 57742155, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of ethyl 2-(4-(2-chloroacetamido)-3-hydroxyphenyl)propanoate (110 mg, 0.385 mmol) in acetone (10 mL) was added potassium carbonate (61 mg). the reaction mixture was refluxed for 3 hrs then cooled to room temperature. The mixture was diluted with H2O and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel using EtOAc:hexanes (1:2) as eluent.

Aufarbeitung

  1. temperaturethe reaction mixture was refluxed for 3 hrs
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe residue was purified by flash column chromatography on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-f9b4c14b10954a1d9b818652dd0eacec
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084484B2

Notizen zur Reaktion

Wird geladen…