Nitric Acid → HCID 57742139, Verbindung

HRID 660311Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660311
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[N+:15]([O-])([OH:17])=[O:16]>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][C:7]=1[N+:15]([O-:17])=[O:16]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 13356241HCID 13356241, Verbindung

Produkt 1

HCID 57742139HCID 57742139, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Ethyl 2-(3-hydroxyphenyl)propanoate (2.51 g, 12.9 mmol) in acetic acid (20 mL) was added nitric acid (60-62%, 1.45 g, 13.8 mmol) at room temperature. The mixture was stirred for 15 minutes at room temperature. The reaction mixture was poured into ice water (100 mL) and extracted with EtOAc. The organic layer was dried with MgSO4 and filtered. EtOAc was removed by evaporation. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=6/1.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried with MgSO4
  3. filtrationfiltered
  4. customEtOAc was removed by evaporation
  5. customThe residue was purified by column chromatography
  6. washeluting with n-Hexane/EtOAc=6/1

Quellen und Nachweise

ORD-Eintrag
ord-9c4ab8006cd3451dafe562dfd24a62fe
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084484B2

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