Ethyl 2-(4-nitrophenyl)propionate → Ethyl 2-(4-aminophenyl)propanoate

HRID 660340Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 660340
[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)[CH3:6])[CH3:2]>C1COCC1.CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:16])[CH:5]([C:7]1[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=1)[CH3:6])[CH3:2]

Komponenten

5

Edukt 1

HCID 3016550Ethyl 2-(4-nitrophenyl)propionate

Produkt 1

HCID 118009Ethyl 2-(4-aminophenyl)propanoate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 2 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.

Aufarbeitung

  1. customat room temperature
  2. filtrationThe mixture is filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-181820bc4fac4d6ea829fb39dbeaddc2
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084484B2

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