Ammonium Chloride → HCID 68838918, Verbindung

HRID 660705

Reaktionsgleichung

Reaktionsgleichung von HRID 660705
[C:1]1([C:7](=[O:16])[CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C.[CH2:27]([O:34][C:35]1[CH:40]=[C:39]([CH2:41]Br)[CH:38]=[CH:37][C:36]=1[N+:43]([O-:45])=[O:44])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[Cl-].[NH4+]>C1COCC1.CCOC(C)=O>[CH2:9]([CH:8]([CH2:41][C:39]1[CH:38]=[CH:37][C:36]([N+:43]([O-:45])=[O:44])=[C:35]([O:34][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:40]=1)[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:16])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Komponenten

7

Edukt 4

HCID 25517Ammonium ChlorideHCID 64802DihydrochalconeHCID 2733832Lithium HexamethyldisilazideHCID 621150422-Benzyloxy-4-bromomethyl-1-nitrobenzene

Produkt 1

HCID 68838918HCID 68838918, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

To a solution of 1,3 diphenylpropan-1-one (231 mg, 1.1 mmol) in THF (2.5 mL) at −78° C. is added dropwise LiHMDS (1M in THF, 1.3 mL), over a period of 15 min. The mixture is stirred at −78° C. for 30 min then a solution of 2-benzyloxy-4-bromomethyl-1-nitrobenzene (321 mg, 1 mmol) in THF (2.5 mL) is added over a period of 15 min. The mixture is stirred at −78° C. for 15 min, then allowed to slowly warm to RT and stirred there for 45 min. The mixture is diluted with EtOAc, cooled to −25° C. and a solution of saturated ammonium chloride is added dropwise. The organic phase is washed with saturated ammonium chloride and brine, dried over MgSO4, filtered and concentrated to afford crude product which is purified using flash chromatography to give the title compound as a gum.

Aufarbeitung

  1. stirringThe mixture is stirred at −78° C. for 15 min
  2. temperatureto slowly warm to RT
  3. stirringstirred there for 45 min
  4. temperaturecooled to −25° C.
  5. washThe organic phase is washed with saturated ammonium chloride and brine
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customto afford crude product which
  10. customis purified

Quellen und Nachweise

ORD-Eintrag
ord-e10ddec916b449c189cda98ce9fb9451
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084448B2

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