Lithium Hydroxide → HCID 58011978, Verbindung
Reaktionsgleichung
C[O:2][C:3](=[O:18])[CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:17].[OH-].[Li+]>CO>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]2[NH:7][C:6](=[O:17])[N:5]([CH2:4][C:3]([OH:18])=[O:2])[CH:9]=2)=[CH:11][CH:12]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
770 mg (2.89 mmol) of methyl[4-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 232A are placed in 20 ml methanol, treated with 5.8 ml of 1 M aqueous lithium hydroxide solution and stirred for 18 hrs at room temperature. The methanol is then removed on the rotary evaporator and the residue is acidified with 1 N hydrochloric acid. The resulting precipitate is filtered off at the pump, washed with water and dried under high vacuum. 690 mg (94% of theory) of the target compound are thus obtained.