Ammonium Chloride → 1,2,3,4-Tetrahydro-6-hydroxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

HRID 66115Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66115
C([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]([OH:15])[CH:10]([CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]1)[CH2:9][CH2:8]2)(=O)C.[Cl-].[NH4+]>[OH-].[K+].O>[OH:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]([OH:15])[CH:10]([CH2:16][N:17]1[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:19][CH2:18]1)[CH2:9][CH2:8]2

Komponenten

5

Edukt 2

HCID 25517Ammonium ChlorideHCID 227555641,2,3,4-Tetrahydro-6-acetoxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

Produkt 1

HCID 227555881,2,3,4-Tetrahydro-6-hydroxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 14797Potassium HydroxideLösungsmittel

Versuchsvorschrift

1,2,3,4-Tetrahydro-6-acetoxy-2-[(4-phenyl-1-piperazinyl)methyl]-1-naphthalenol (3.96 g) in 32 ml of 8% methanolic potassium hydroxide is refluxed for 3 minutes under argon, cooled to room temperature and diluted with sufficient water to effect solution. Excess aqueous ammonium chloride solution is added dropwise, with stirring, and the reaction mixture is extracted several times with methylene chloride. The organic extracts are dried, filtered and evaporated to give the title A compound.

Aufarbeitung

  1. extractionthe reaction mixture is extracted several times with methylene chloride
  2. customThe organic extracts are dried
  3. filtrationfiltered
  4. customevaporated
  5. customto give the title A compound

Quellen und Nachweise

ORD-Eintrag
ord-80e8e50a194049f2ae57718d42a636ea
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04130646

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