O.CC(C)([O-])C.[Na+].CS(O)(=O)=O.[CH2:13]([C@@H:15]1[CH2:24][C@H:23]([NH2:25])[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([C:26]([F:29])([F:28])[F:27])[CH:21]=2)[NH:16]1)[CH3:14]>C1(C)C=CC=CC=1>[CH2:13]([C@@H:15]1[CH2:24][C@H:23]([NH2:25])[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([C:26]([F:29])([F:27])[F:28])[CH:21]=2)[NH:16]1)[CH3:14]Water (0.6 ml) and sodium tert-butoxide (1.27 g) were added to a solution of (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine methane-sulfonate (3 g) in toluene (15 ml) and the mixture was stirred at 80° C. for an hour, then water (15 ml) was added, and the mixture was further stirred at 80° C. for an hour. The reaction mixture was cooled to room temperature, and the organic layer was separated, washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo to give the titled compound.
Wird geladen…
