Methane → 4,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

HRID 66148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66148
C([O:3][C:4]([C:6]1[N:11](CCC)[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])C.Cl.C>>[O:25]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:11][C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]1=2

Komponenten

4

Edukt 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 53707130HCID 53707130, Verbindung

Produkt 1

HCID 227556674,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

Versuchsvorschrift

A mixture of 4,7-dihydro-4,7-dioxo-6-propoxy-1-propyl-1H-cyclohepta[b]pyridine-2-carboxlic acid ethyl ester (3.8 g, described in Example 22) and 19% hydrochloric acid (113 ml) is refluxed for 30 minutes. Charcoal is added and the hot mixture is filtered. The filtrate is cooled to room temperature and the crystalline precipitate is collected and dried to obtain the title compound, mp > 250° C.

Aufarbeitung

  1. temperatureis refluxed for 30 minutes
  2. filtrationthe hot mixture is filtered
  3. customthe crystalline precipitate is collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-768ff5e905c442d292fe4bdf6acf1096
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04130649

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