Hydrochloric Acid → HCID 59376005, Verbindung

HRID 661490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 661490
[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:16])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([O:13]CC)=[O:12].Cl>[Li+].[OH-]>[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[O:16])[CH2:6][CH2:7][CH2:8][C:9]=2[C:10]=1[C:11]([OH:13])=[O:12]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59376018ethyl 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate

Produkt 1

HCID 59376005HCID 59376005, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3939Lithium HydroxideLösungsmittel

Versuchsvorschrift

ethyl 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (S3) 1.0 g (4.5 mmol) in 25 ml aq. LiOH solution (1 mol/L) was stirred for 48 hours at 70° C. The mixture was poured into the ice water, then acidified with 6 mol/L HCl to pH 1 to 2. The gray solid was collected by filtration, washed with water and dried in vacuum condition to give 0.64 g (74%) of the titled compound.

Aufarbeitung

  1. filtrationThe gray solid was collected by filtration
  2. washwashed with water
  3. customdried in vacuum condition

Quellen und Nachweise

ORD-Eintrag
ord-10fdbaf725924729932594e4a9be5044
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084621B2

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