4-(1-Benzylpiperidin-4-yl)morpholine → 4-Morpholinopiperidine

HRID 661599Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 661599
C1(C[N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)C=CC=CC=1.[H][H]>CO.[Pd]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1

Komponenten

5

Edukt 2

HCID 7838314-(1-Benzylpiperidin-4-yl)morpholineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 7957244-Morpholinopiperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

41.59 g (0.16 Mol) 4-[1-(phenylmethyl)-4-piperidinyl]-morpholine (N) are dissolved in 400 mL methanol, combined with 5.2 g palladium on activated charcoal (10%) and hydrogenated for 18 hours at ambient temperature with 50 psi hydrogen. The catalyst is filtered off and the filtrate is evaporated down. A colourless oil remains, which crystallises after a short time.

Aufarbeitung

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated down
  3. customA colourless oil remains, which crystallises after a short time

Quellen und Nachweise

ORD-Eintrag
ord-2aa98d9edb644eddbb8c48d568b1325a
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08084634B2

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