Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione

Reaktionsgleichung

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6](=[CH:10][CH:11]=1)[C:7](O)=[O:8].C(OC(=O)C)(=O)C>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]2[C:12](=[O:14])[O:13][C:7](=[O:8])[C:6]2=[CH:10][CH:11]=1

Komponenten

Edukt 2

HCID 7918Acetic Anhydride

HCID 5990394-(Trifluoromethyl)phthalic acid

Produkt 1

HCID 127177895-(Trifluoromethyl)isobenzofuran-1,3-dioneAusbeute 74,7 %

Versuchsvorschrift

4-Trifluoromethylphthalic acid (106.6 g.) and acetic anhydride (215 cc.) are heated at the reflux temperature for 30 minutes. After concentrating the mixture under reduced pressure (30 mm.Hg), the residue is stirred with cyclohexane (420 cc.). After filtration and drying, 4-trifluoromethylphthalic anhydride (73.5 g.), melting at 54° C., is obtained.

Aufarbeitung

concentrationAfter concentrating the mixture under reduced pressure (30 mm.Hg)
filtrationAfter filtration
customdrying

Quellen und Nachweise

ORD-Eintrag: ord-32b5d7c475b04f468a9c379ef539b463
Quelldatensatz: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04131674

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