Nitric Acid → 6-Methyl-2-nitropyridin-3-ol

HRID 66353

Reaktionsgleichung

Reaktionsgleichung von HRID 66353
[OH:1][C:2]1[CH:3]=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>>[OH:1][C:2]1[C:3]([N+:9]([O-:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 142752-Methyl-5-hydroxypyridine

Produkt 1

HCID 848016-Methyl-2-nitropyridin-3-ol

Reaktionsbedingungen

Temperatur
6 °C

Versuchsvorschrift

To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.

Aufarbeitung

  1. additionof ice cold concentrated sulfuric acid was added 10.9 g
  2. temperatureto warm to room temperature overnight
  3. stirringwith stirring
  4. customthe precipitate was collected
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f3b692fa11714b5f803b8edbedaeef34
Quelldatensatz
uspto-grants-1978_12
Patentnummer
US04131677

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