Methanol → 2-Chloro-3-methoxypyrazine

HRID 66733

Reaktionsgleichung

Reaktionsgleichung von HRID 66733
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.[Na].[CH3:10][OH:11]>O>[Cl:1][C:2]1[C:7]([O:11][CH3:10])=[N:6][CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 785752,3-DichloropyrazineHCID 5360545Sodium

Produkt 1

HCID 118048912-Chloro-3-methoxypyrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 0.1 mole of 2,3-dichloropyrazine and 2.3 g. (0.1 mole) of sodium in 160 ml. of anhydrous methanol is refluxed 5-10 hours, and poured into water. The product is extracted with ether or chloroform and recrystallized from a suitable solvent such as ethanol to give pure 2-chloro-3-methoxypyrazine.

Aufarbeitung

  1. extractionThe product is extracted with ether or chloroform
  2. customrecrystallized from a suitable solvent such as ethanol

Quellen und Nachweise

ORD-Eintrag
ord-5d9f55db9a254bf2810c8ee901af2276
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343802

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