Methanol → 2-Chloro-3-methoxypyrazine
Reaktionsgleichung
[Cl:1][C:2]1[C:7](Cl)=[N:6][CH:5]=[CH:4][N:3]=1.[Na].[CH3:10][OH:11]>O>[Cl:1][C:2]1[C:7]([O:11][CH3:10])=[N:6][CH:5]=[CH:4][N:3]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 0.1 mole of 2,3-dichloropyrazine and 2.3 g. (0.1 mole) of sodium in 160 ml. of anhydrous methanol is refluxed 5-10 hours, and poured into water. The product is extracted with ether or chloroform and recrystallized from a suitable solvent such as ethanol to give pure 2-chloro-3-methoxypyrazine.
Aufarbeitung
- extractionThe product is extracted with ether or chloroform
- customrecrystallized from a suitable solvent such as ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-5d9f55db9a254bf2810c8ee901af2276
- Quelldatensatz
- uspto-grants-1982_08
- Patentnummer
- US04343802
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