Dimethylformamide → 3-Cyanophenoxyacetonitrile

HRID 66769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66769
[C:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.Cl[CH2:22][C:23]#[N:24]>O>[C:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O:9][CH2:22][C:23]#[N:24])#[N:2]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 133943-Cyanophenol

Produkt 1

HCID 205290533-Cyanophenoxyacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

The compound 3-cyanophenoxyacetonitrile was prepared by heating 20.0 g of 3-cyanophenol, 30.1 g of anhydrous potassium carbonate and 30 ml of dimethylformamide with stirring in a 250 ml round-bottomed three-necked flask to 70° C. and then 12.7 g of chloroacetonitrile was added dropwise over a 15 minute period with cooling. The temperature of the mixture was held at 70°-80° C. for three hours, after which time the reaction mixture was poured into approximately 700 ml of ice and water which resulted in crystal formation. The crystals were separated by filtering and then washed thoroughly with water. After drying in a vacuum oven, a tan solid 3-cyanophenoxyacetonitrile was obtained.

Aufarbeitung

  1. customThe compound 3-cyanophenoxyacetonitrile was prepared
  2. temperaturewith cooling
  3. customresulted in crystal formation
  4. customThe crystals were separated
  5. filtrationby filtering
  6. washwashed thoroughly with water
  7. customAfter drying in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-cb74929a9ac24f9fa00d273291c0ed94
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343808

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