Hydrochloric Acid → 8-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

HRID 66776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66776
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([O:15]CC)=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25].[OH-].[Na+].C(O)C.Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[CH:10][C:9]([C:13]([OH:15])=[O:14])=[C:8]2[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[CH3:25]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 130384398-Methoxy-4-o-tolylamino-quinoline-3-carboxylic acid ethyl ester

Produkt 1

HCID 130384408-Methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of Ethyl 8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate, 15.00 g (0.0445 mole), 100 ml of 3 N sodium hydroxide solution and 100 ml of ethanol was stirred at room temperature for 16 hours. The mixture was diluted with 300 ml of water and acidified to pH 6.8 with 6 N hydrochloric acid solution. The precipitate was collected by filtration, washed in succession with water and acetone and air dried for about 1.5 hr. Weight of solid was 13.41 g (98%), m.p. 272° C. (d).

Aufarbeitung

  1. filtrationThe precipitate was collected by filtration
  2. washwashed in succession with water and acetone and air
  3. customdried for about 1.5 hr

Quellen und Nachweise

ORD-Eintrag
ord-01be616c14cc409ba37998d98552c46b
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343804

Notizen zur Reaktion

Wird geladen…