4-Bromophenylhydrazine hydrochloride → N-(6-bromo-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

HRID 66784

Reaktionsgleichung

Reaktionsgleichung von HRID 66784
O=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([NH:8][C:9](=[O:11])[CH3:10])[CH2:3]1.Cl.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20]N)=[CH:16][CH:15]=1>CC(O)=O>[Br:13][C:14]1[CH:15]=[C:16]2[C:17](=[CH:18][CH:19]=1)[NH:20][C:2]1[CH2:3][CH:4]([NH:8][C:9](=[O:11])[CH3:10])[CH2:5][CH2:6][C:7]2=1

Komponenten

4

Edukt 2

HCID 121574-Bromophenylhydrazine hydrochlorideHCID 20529251N-(3-oxocyclohexyl)acetamide

Produkt 1

HCID 20529232N-(6-bromo-1,3,4,9-tetrahydro-2H-carbazol-2-yl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A solution of 0.05 mol of N-(3-oxocyclohexyl)acetamide in 100 ml of glacial HOAc was stirred and heated at 80° C. while adding during 15-30 minutes a warm solution of 0.05 mol of 4-bromophenylhydrazine hydrochloride in 300 ml of glacial HOAc. After an additional 3 hr at 85°, most of the HOAc was evaporated. The residue was triturated with H2O, until solid, the resulting solid was filtered, and recrystallized from ethanol to give the title compound, mp 210°-211°.

Aufarbeitung

  1. custommost of the HOAc was evaporated
  2. customThe residue was triturated with H2O, until solid
  3. filtrationthe resulting solid was filtered
  4. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2bfa85bc87604b8b955eec3ed01d9979
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343812

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