Water → 2-[2-(4-Acetamido-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66899Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 66899
[CH2:1]([O:3][C:4](=[O:29])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH3:20])[C:13]([C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=1)=[C:12]2[CH3:28])([CH3:7])[CH3:6])[CH3:2].C(N(CC)CC)C.[C:37](Cl)(=[O:39])[CH3:38].O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:29])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH3:20])[C:13]([C:21]1[CH:22]=[CH:23][C:24]([NH:27][C:37](=[O:39])[CH3:38])=[CH:25][CH:26]=1)=[C:12]2[CH3:28])([CH3:6])[CH3:7])[CH3:2]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 538662912-[2-(4-amino-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Produkt 1

HCID 537871562-[2-(4-Acetamido-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

One gram (2.53 m mole) of 2-[2-(4-amino-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester and 0.25 g (2.5 m mole) of triethylamine were dissolved in 15 ml of chloroform and 0.2 g (2.55 m mole) of acetyl chloride were added dropwise while ice-cooling. After a few hours at room temperature the reaction mixture was mixed with water and extracted with chloroform. The chloroform extracts were dried and evaporated, and the residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1)).

Aufarbeitung

  1. temperaturecooling
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts were dried
  4. customevaporated
  5. customthe residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1))

Quellen und Nachweise

ORD-Eintrag
ord-edf9e13b99db4fcbb578d2343b4e2b70
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04343811

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