Water → 2-(azepan-4-yl)ethanol

HRID 67171Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 67171
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][C:15](=O)[CH2:14]1)(OCC)=[O:8].O>O1CCCC1>[OH:8][CH2:7][CH2:12][CH:13]1[CH2:20][CH2:19][CH2:18][NH:17][CH2:15][CH2:14]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 20528706HCID 20528706, VerbindungHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 205287192-(azepan-4-yl)ethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a stirred slurry of lithium aluminium hydride (5.70 g) in dry tetrahydrofuran (100 ml) was added β-carbethoxymethyl-caprolactam (10.3 g) in dry tetrahydrofuran (150 ml) over a period of 30 minutes. The mixture was refluxed for 2.5 hours, cooled and treated very slowly with water. The precipitate was filtered off and the filtrate was evaporated to yield the title compound as a viscous oil, which was used in the next step without purification.

Aufarbeitung

  1. temperatureThe mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. filtrationThe precipitate was filtered off
  4. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3da496ef82a942098c3b16ad99fa38de
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04345071

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