Hydrochloric Acid → 3-[3-(4-Methoxyphenyl)propyl]glutaric acid

HRID 67207

Reaktionsgleichung

Reaktionsgleichung von HRID 67207
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][CH:12]=O)=[CH:5][CH:4]=1.C([CH2:16][C:17]([OH:19])=[O:18])#N.[OH-:20].[Na+].Cl.[CH2:23]([CH2:26][O:27]C)OC>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][CH:12]([CH2:23][C:26]([OH:27])=[O:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:7][CH:8]=1

Komponenten

7

Edukt 5

HCID 313Hydrochloric AcidHCID 80711,2-DimethoxyethaneHCID 9740Cyanoacetic acidHCID 14798Sodium HydroxideHCID 104875554-(4-Methoxyphenyl)butanal

Produkt 1

HCID 205288273-[3-(4-Methoxyphenyl)propyl]glutaric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4(4-Methoxyphenyl)butyraldehyde (5.34 g) is reacted with cyanoacetic acid (5.15 g) and sodium hydroxide (2.74 g) in a mixture of glyme (50 ml) and water (60 ml). The mixture is treated with hydrochloric acid and processed as described in Example 2A to afford the title compound (2.1 g) which on crystallization from ethyl acetate-chloroform-hexane had a melting point of 71°-73° C.

Quellen und Nachweise

ORD-Eintrag
ord-10b05713b21542bd86cd938be251207c
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04345096

Verknüpfte Notizen

Wird geladen…