Acetic Anhydride → N-(2-(4-Methoxyphenyl)ethyl)acetamide

HRID 6753

Reaktionsgleichung

Reaktionsgleichung von HRID 6753
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6](NCC)=[CH:5][CH:4]=1.[CH2:12]([N:14](CC)[CH2:15][CH3:16])[CH3:13].C(OC(=O)C)(=[O:21])C>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:13][CH2:12][NH:14][C:15](=[O:21])[CH3:16])=[CH:7][CH:8]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 11804947N-Ethyl-4-methoxybenzenamine

Produkt 1

HCID 584258N-(2-(4-Methoxyphenyl)ethyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of (4-methoxy-phenyl)-ethylamine (10 g, Aldrich, U.S.A.) and triethylamine (10.1 mL) in dichloromethane (200 mL) was added acetic anhydride (7.4 g). The mixture was stirred at rt for 3 h and was washed successively with hydrochloric acid (1 M, 100 mL), 10% aqueous potassium carbonate (100 mL) and brine (100 mL). The dichloromethane layer was dried over sodium sulfate and filtered. The filtrate was evaporated to afford N-[2-(4-methoxy-phenyl)-ethyl]-acetamide (13.0 g).

Aufarbeitung

  1. washwas washed successively with hydrochloric acid (1 M, 100 mL), 10% aqueous potassium carbonate (100 mL) and brine (100 mL)
  2. dry with materialThe dichloromethane layer was dried over sodium sulfate
  3. filtrationfiltered
  4. customThe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-71c59c4825cc4dd98d2a6241a5eac55b
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084154B2

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