Water → 4-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenylimino)-3-methyl-4-thiazoline

HRID 67753Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 67753
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2(O)[CH2:13][S:12][C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[N:10]2[CH3:22])=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:27])[CH3:26].O>CO.C(N(CC)CC)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]([CH3:22])[C:11](=[N:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[S:12][CH:13]=2)=[CH:5][C:4]=1[S:24](=[O:29])(=[O:28])[N:25]([CH3:26])[CH3:27]

Komponenten

5

Edukt 2

HCID 962WaterHCID 705316964-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide

Produkt 1

HCID 205271334-(4-Chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenylimino)-3-methyl-4-thiazoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

10.8 g of 4-(4-chloro-3-dimethylsulfamoylphenyl)-2-(2-chlorophenyl-imino)-3-methylthiazolidin-4-ol hydrobromide are heated at the boil in a mixture of 100 ml of methanol and 10 ml of triethylamine for 30 minutes and the reaction mixture is then poured into an equal volume of water. The resulting mixture is stirred for about 2 hours at room temperature and the crystals are filtered off and recrystallized from ethanol. Melting point 153°-156° C.

Aufarbeitung

  1. filtrationthe crystals are filtered off
  2. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-09a63501d0e54ad08018f34b9ad20fe8
Quelldatensatz
uspto-grants-1982_08
Patentnummer
US04346088

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