Dimethylformamide → (2E)-3-(4-Chlorophenyl)acryloyl chloride

HRID 6797Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 6797
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([OH:12])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:16])=O.CN(C)C=O>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([Cl:16])=[O:12])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6377974-Chlorocinnamic acid

Produkt 1

HCID 11252649(2E)-3-(4-Chlorophenyl)acryloyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (2E)-3-(4-chlorophenyl)prop-2-enoic acid (2.0 g, 11 mmol) in 50 mL methylene chloride was added oxalyl chloride (1.05 mL, 12.1 mmol) and N,N-dimethylformamide (0.05 mL, 0.6 mmol). The resulting mixture was stirred at r.t. for 6 h. The solvent was removed under vacuum. The resulting solid was diluted with hexanes and the solvent removed under vacuum to provide an off-white solid which was used without further purification.

Aufarbeitung

  1. customThe solvent was removed under vacuum
  2. additionThe resulting solid was diluted with hexanes
  3. customthe solvent removed under vacuum
  4. customto provide an off-white solid which
  5. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-98ba0a4789094cd8bd645b484b6e0ba8
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084156B2

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