Acetic Acid → HCID 15987642, Verbindung

HRID 68540Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 68540
[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH3:14])[C:10](=[O:15])C(C#N)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:19]([OH:22])(=[O:21])[CH3:20]>>[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH3:14])[C:10](=[O:15])[C:20]([C:19]([OH:22])=[O:21])=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 47801582-Phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Produkt 1

HCID 15987642HCID 15987642, VerbindungAusbeute 45,7 %

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

Intermediate d (7.6 g, 0.033 mol) was added to a mixed solvent of glacial acetic acid (100 mL) and HCl (72 mL, 0.86 mol). The mixture was warmed up to 120° C. and reacted under reflux for 4 h. The solvent was evaporated off. To the obtained fraction was added water (400 mL). The mixture was filtered by suction and dried to produce a solid (3.7 g) in a yield of 45.7%.

Aufarbeitung

  1. customreacted
  2. temperatureunder reflux for 4 h
  3. customThe solvent was evaporated off
  4. additionTo the obtained fraction was added water (400 mL)
  5. filtrationThe mixture was filtered by suction
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b674334b927e4922a96b129f12ed46d7
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822465B2

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