1-Benzyl-4-(pyridin-3-yl)piperazine → 1-(Pyridin-3-yl)piperazine

HRID 68552

Reaktionsgleichung

Reaktionsgleichung von HRID 68552
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:15]=1

Komponenten

4

Edukt 1

HCID 218154091-Benzyl-4-(pyridin-3-yl)piperazine

Produkt 1

HCID 4372341-(Pyridin-3-yl)piperazineAusbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

31.3 g 1-Benzyl-4-pyridin-3-yl-piperazin was hydrogenated at 5 bar on 4 g 10% palladium on charcoal in 300 mL methanol at 50° C. for 25 h. The reaction was filtered. The filtrate was evaporated and purified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1)). 12.5 g of the desired compound was obtained.

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. customThe filtrate was evaporated
  3. custompurified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1))

Quellen und Nachweise

ORD-Eintrag
ord-fe990aa700d7442d94c6508d1f0b7864
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822464B2

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