1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile → 1-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-one

HRID 68763

Reaktionsgleichung

Reaktionsgleichung von HRID 68763
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]#[N:12])[CH2:7][CH2:6]2)OCC1.[OH:13][NH:14][C:15](=N)[CH:16]([CH3:18])[CH3:17]>>[CH:16]([C:15]1[N:12]=[C:11]([N:8]2[CH2:7][CH2:6][C:5](=[O:1])[CH2:10][CH2:9]2)[O:13][N:14]=1)([CH3:18])[CH3:17]

Komponenten

3

Edukt 2

HCID 866782101,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrileHCID 178449908HCID 178449908, Verbindung

Produkt 1

HCID 669153481-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-one

Versuchsvorschrift

The title compound is prepared from 1,4-dioxa-8-aza-spiro[4.5]decane-8-carbonitrile and N-hydroxy-isobutyramidine following a procedure analogous to that described in Intermediate 5. LC (method 6): tR=1.56 min; Mass spectrum (ESI+): m/z=254 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-ad2d13b10f764b4ea5437ea707fdebd6
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822471B2

Verknüpfte Notizen

Wird geladen…