Iodine → HCID 178516694, Verbindung

HRID 69043

Reaktionsgleichung

Reaktionsgleichung von HRID 69043
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[CH:10][CH:9]=1.[I:18]I.C(=O)([O-])O.[Na+].S([O-])([O-])=O.[Na+].[Na+]>O.CN(C=O)C>[I:18][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:8]=1[OH:7])=[CH:16][CH:15]=[CH:14][CH:13]=2

Komponenten

8

Edukt 5

HCID 807IodineHCID 11430Potassium CarbonateHCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 178516385quinolin-4-ol

Produkt 1

HCID 178516694HCID 178516694, VerbindungAusbeute 96,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Potassium carbonate (5.2 g) was added to a DMF solution (50 ml) of 4-hydroxy quinoline (5.0 g) and the mixture was stirred. Iodine (9.6 g) was added to the mixture, followed by stirring at room temperature for 3 hours. A saturated sodium hydrogencarbonate aqueous solution (73 ml) of 25% sodium sulfite, and water (50 ml) were added to the reaction mixture. The mixture was stirred and the precipitated insoluble matter was separated. The filtrate was washed with water and dried to give the title compound (9.0 g) as a white powder.

Aufarbeitung

  1. stirringby stirring at room temperature for 3 hours
  2. stirringThe mixture was stirred
  3. customthe precipitated insoluble matter was separated
  4. washThe filtrate was washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-95f11b102de64b3bbe148233931cfbd0
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822453B2

Verknüpfte Notizen

Wird geladen…