Butanal → 1,1-Di-(5-fluoroindol-3-yl)-butane

HRID 6942

Reaktionsgleichung

Reaktionsgleichung von HRID 6942
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11](=O)[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]([C:5]1[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)[NH:7][CH:6]=1)[CH2:12][CH2:13][CH3:14]

Komponenten

3

Edukt 2

HCID 261ButanalHCID 678615-Fluoroindole

Produkt 1

HCID 220193091,1-Di-(5-fluoroindol-3-yl)-butaneAusbeute 45 %

Versuchsvorschrift

This was prepared in the same way as described in example 2/2 starting from 5-fluoroindole and butyraldehyde. The reaction, however, was heated under reflux for 24 hours. The end product was isolated and purified by chromatography on an SiO2 column using a hexane:ethyl ether gradient ranging from 7:3 to 4:6 as the eluent. Yield 45%.

Aufarbeitung

  1. customThis was prepared in the same way
  2. customThe reaction
  3. temperaturehowever, was heated
  4. temperatureunder reflux for 24 hours
  5. customThe end product was isolated
  6. custompurified by chromatography on an SiO2 column

Quellen und Nachweise

ORD-Eintrag
ord-40492c21a69f46b88fd0fa2d519864ca
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07084166B2

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