Butanal → 1,1-Di-(7-azaindol-3-yl)-butane

Reaktionsgleichung

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[CH:3]=[CH:2]1.[CH:10](=O)[CH2:11][CH2:12][CH3:13]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[C:3]([CH:10]([C:3]2[C:4]3[C:9](=[N:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)[CH2:11][CH2:12][CH3:13])=[CH:2]1

Komponenten

Edukt 2

HCID 261Butanal

HCID 92221H-Pyrrolo(2,3-b)pyridine

Produkt 1

HCID 220192831,1-Di-(7-azaindol-3-yl)-butaneAusbeute 15 %

Versuchsvorschrift

ST 1436 was prepared as described in example 2/2 from 7-azaindole and butyraldehyde. The reaction, however, was heated under reflux for 48 hours. The end product was isolated and purified chromatographically on a silica column eluting with a CH2Cl2:CH3COCH3 gradient ranging from 9:1 to 4:6. Yield 15%.

Aufarbeitung

customST 1436 was prepared
customThe reaction
temperaturehowever, was heated
temperatureunder reflux for 48 hours
customThe end product was isolated
custompurified chromatographically on a silica column
washeluting with a CH2Cl2

Quellen und Nachweise

ORD-Eintrag: ord-7e699b14c36a4cb1ab9bfad78d80f704
Quelldatensatz: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07084166B2

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