1,3-Dioxolane, 2-(bromomethyl)- → 2-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-([1,3]dioxolan-2-ylmethoxy)-2H-isoquinolin-1-one

HRID 69525

Reaktionsgleichung

Reaktionsgleichung von HRID 69525
[N:1]1([C@@H:6]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[C:22]([OH:27])[CH:23]=5)[C:18]4=[O:28])=[CH:13][C:12]=3[F:29])[CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:31][CH:32]1[O:36][CH2:35][CH2:34][O:33]1>>[N:1]1([C@@H:6]2[CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH:26]=[CH:25][C:24]5[C:19](=[CH:20][CH:21]=[C:22]([O:27][CH2:31][CH:32]6[O:36][CH2:35][CH2:34][O:33]6)[CH:23]=5)[C:18]4=[O:28])=[CH:13][C:12]=3[F:29])[CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Komponenten

3

Edukt 2

HCID 780681,3-Dioxolane, 2-(bromomethyl)-HCID 689893502-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one

Produkt 1

HCID 579166072-((R)-4-[1,3']Bipyrrolidinyl-1'-yl-3-fluoro-phenyl)-6-([1,3]dioxolan-2-ylmethoxy)-2H-isoquinolin-1-one

Versuchsvorschrift

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-hydroxy-2H-isoquinolin-1-one was reacted with 2-Bromomethyl-[1,3]dioxolane by method K. The product with the molecular weight of 479.56 (C27H30FN3O4) was obtained in this way; MS (ESI): 480 (M+H+).

Aufarbeitung

  1. customThe product with the molecular weight of 479.56 (C27H30FN3O4) was obtained in this way

Quellen und Nachweise

ORD-Eintrag
ord-f085abbd83314c0882a27a64d6d08f74
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822495B2

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