HCID 17948959, Verbindung → 4-(2,2-Difluoroethyl)pyrrolidin-2-one
Reaktionsgleichung
[F:1][C:2]([F:10])=[CH:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1>[Pd].CO>[F:1][CH:2]([F:10])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 4-(2,2-difluoroethenyl)pyrrolidin-2-one a1 (2.8 g, 18.77 mmol, 1 eq) and palladium on charcoal (10% Wt, 300 mg) in methanol (500 ml) is stirred overnight under an hydrogen atmosphere (40 psi) at room temperature. The reaction mixtured is filtered over celite and the solvent is removed under reduced pressure to afford 4-(2,2-difluoroethyl)pyrrolidin-2-one a11 which can be used in the next step without any further purification.
Aufarbeitung
- customThe reaction
- filtrationmixtured is filtered over celite
- customthe solvent is removed under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-f18b7aa74a03440a9e73c6b6bacb5116
- Quelldatensatz
- uspto-grants-2014_09
- Patentnummer
- US08822508B2
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