Ammonium Hydroxide → cis-2-Aminocyclohexanecarboxamide
Reaktionsgleichung
C[O:2][C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][CH2:7][C@@H:6]1[NH2:11])=O.[OH-].[NH4+:13]>C1(C)C=CC=CC=1>[NH2:11][C@H:6]1[CH2:7][CH2:8][CH2:9][CH2:10][C@H:5]1[C:3]([NH2:13])=[O:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
cis-2-Aminocyclohexanecarboxylic acid methyl ester (2.20 g, 14.0 mmol) was treated with aqueous ammonium hydroxide (40 mL) in toluene (40 mL) and stirred vigorously at room temperature for 16 h. The reaction was concentrated to dryness in vacuo and azeotroped with toluene (50 mL). The crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification: 1H NMR (400 MHz, DMSO-d6) δ 7.78 (2 H, s br), 7.67 (s, 1 H), 7.25 (s, 1 H), 1.87 (m, 2 H), 1.60 (m, 4 H), 1.41 (m, 4 H).
Aufarbeitung
- concentrationThe reaction was concentrated to dryness in vacuo
- customazeotroped with toluene (50 mL)
- customThe crude product, cis-2-aminocyclohexanecarboxylic acid amide, was used in the next reaction without purification
Quellen und Nachweise
- ORD-Eintrag
- ord-fc1c3c23629140928ac9e042705804cc
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07084178B2
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