Lithium Hydroxide → 2-Bromo-1,3-thiazole-4-carboxylic acid

Temperatur

70 °C

A mixture of methyl 2-bromo-1,3-thiazole-4-carboxylate (4.2 g, 18.9 mmol), THF (120 mL) and 1N lithium hydroxide (50 mL) was heated at 70° C. for 1 h. The organic solvent was removed in vacuo. The residual aqueous solution was cooled to 0-5° C. and acidified to pH1 with 1N HCl solution. The tile compound was obtained by filtration, as a white solid.

1. customThe organic solvent was removed in vacuo
2. temperatureThe residual aqueous solution was cooled to 0-5° C.
3. customThe tile compound was obtained by filtration, as a white solid

ORD-Eintrag

ord-0b0ecf0743b940e48c436651d98251dc

Quelldatensatz

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08822518B2