1-Naphthol → 2-(4-Chlorobutyryl)-1-naphthol

HRID 703886

Reaktionsgleichung

Reaktionsgleichung von HRID 703886
[C:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][CH2:14][CH2:15][C:16](O)=[O:17].B(F)(F)F.CCOCC>O>[Cl:12][CH2:13][CH2:14][CH2:15][C:16]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1]=1[OH:11])=[O:17]

Komponenten

5

Edukt 3

HCID 70051-NaphtholHCID 8000Boron trifluoride etherateHCID 123004-Chlorobutanoic acid

Produkt 1

HCID 156179222-(4-Chlorobutyryl)-1-naphtholAusbeute 38,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A mixture of 1-naphthol (15.14 g, 0.105 mole), 4-chlorobutyric acid (9.90 mL, 0.100 mole), and boron trifluoride etherate (75 mL) was heated on a steam bath for 4 hours. The mixture was then treated slowly with 100 mL of water, and heating continued for 30 minutes. The mixture was poured into water, stirred, and the solution decanted. The residue was triturated with water, then crystallized from ethanol to provide the title compound (9.50 g, 38%) as a pale green solid, mp 73°-79°.

Aufarbeitung

  1. temperaturewas heated on a steam bath for 4 hours
  2. temperatureheating
  3. customthe solution decanted
  4. customThe residue was triturated with water
  5. customcrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f6f70456936c498884c9c366de5ebcb0
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04985442

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