Water → 4-(2-Phenylethyl)piperidine

HRID 704386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 704386
[C:1]1([CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][N:12](C(OCC)=O)[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O>Br>[C:1]1([CH2:7][CH2:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 20074040Ethyl 4-(2-phenylethyl)piperidine-1-carboxylate

Produkt 1

HCID 43418954-(2-Phenylethyl)piperidineAusbeute 82,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 260Hydrogen BromideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 0.70 g of ethyl 4-(2-phenylethyl)piperidine-1-carboxylate in 6 ml of 47% hydrobromic acid was heated under reflux at 100° C. for 6 hours. A small amount of water was added for dissolution of the resultant crystals, the solution was washed with ether, and the aqueous layer was made alkaline with 20% sodium hydroxide. After salting out with sodium chloride, the aqueous layer was extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 0.42 g of 4-(2-phenylethyl)piperidine.

Aufarbeitung

  1. temperaturewas heated
  2. washthe solution was washed with ether
  3. extractionthe aqueous layer was extracted with ether
  4. washThe organic layer was washed with saturated aqueous solution of sodium chloride
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-de54920d9310412a8fd4fe0c56fe3efe
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04987132

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