Benzylamine → 1-methyl-5-phenyl-3-{(phenylmethyl)-amino}-1H-1,5-benzodiazepine-2,4(3H, 5H)-dione

HRID 704557Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 704557
Br[CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3]1=[O:21].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>O>[CH3:10][N:7]1[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3](=[O:21])[CH:2]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8]1=[O:9]

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 146976583-bromo-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4-(3H, 5H)-dione

Produkt 1

HCID 146976591-methyl-5-phenyl-3-{(phenylmethyl)-amino}-1H-1,5-benzodiazepine-2,4(3H, 5H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 50 mg of the product of Step B and 2 ml of benzylamine was heated at 100° C. for 3 hours and the reaction medium was poured into water. The product obtained was separated, washed, and dried in the presence of phosphoric anhydride to obtain 50 mg of the sought product.

Aufarbeitung

  1. customThe product obtained
  2. customwas separated
  3. washwashed
  4. dry with materialdried in the presence of phosphoric anhydride

Quellen und Nachweise

ORD-Eintrag
ord-eedb9b22640b40bb8f4133c725dde4e3
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04988692

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